Distribution of thioridazine and its metabolites in human tissues and fluids obtained postmortem.

Thioridazine-fluoxetine interaction at the level of the distribution process in vivo.

The aim of the present study was to investigate the effect of the distribution interaction between thioridazine and fluoxetine in vivo. Experiments were carried out on male Wistar rats. Animals received thioridazine and fluoxetine separately or jointly, at a dose of 10 mg/kg ip. Concentrations of thioridazine and its metabolites and fluoxetine in the plasma and tissues were measured at 1 h afte...

Voltammetric Investigation of Thioridazine Using a Carbon Nanocomposite Electrode in Human Biological Samples

An electrochemical method employing a carbon nanocomposite electrode was developed to measure thioridazine. The electrode has been designed by incorporation of montmorillonite nanoclay into the carbon ionic liquid electrode. Surface morphology of the electrodes was done using scanning electron microscopy. Adsorptive stripping voltammetry was applied as a very sensitive analytical method for...

Analysis of sertraline in postmortem fluids and tissues in 11 aviation accident victims.

Sertraline (Zoloft) is a selective serotonin reuptake inhibitor that is a commonly prescribed drug for the treatment of depression, obsessive-compulsive disorder, panic disorder, social anxiety disorder, premenstrual dysphoric disorder and post-traumatic stress disorder. Although the use of sertraline is relatively safe, certain side effects may negatively affect a pilot's performance and becom...

اندازه‌گیری مبودیپین در مایعات بیولوژیک با روش HPLC و کاربرد این دارو در مطالعه فارماکوکینتیک در موش صحرایی An HPLC Method for Determination of Mebudipine in Biological Fluids in Rats and its Application in Pharmacokinetic Study

        Background & Aim: Mebudipine is a calcium antagonist drug which is used to treat blood pressure. A new high performance liquid chromatography(HPLC) system for the determination of a new 1, 4-dihydropyridine, mebudipine, in rat plasma and other biological fluids was developed in this study for the first time. Materials & Methods: To 1 ml of rat plasma and/or other biological fluids, 0.5 ...

Distribution of Paroxetine in Postmortem Fluids and Tissues